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| A NEW APPROACH TO THE RAPID-DETERMINATION OF PROTEIN SIDE-CHAIN CONFORMATIONS |
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| Author(s): TUFFERY P, ETCHEBEST C, HAZOUT S, LAVERY R |
| Source: JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS Volume: 8 Issue: 6 Pages: 1267-1289 Published: JUN 1991 |
| Times Cited: 220 References: 14 |
| Abstract: Two efficient algorithms have been developed which allow amino acid side chain conformations to be optimized rapidly for a given peptide backbone conformation. Both these approaches are based on the assumption that each side chain can be represented by a small number of rotameric states. These states have been obtained by a dynamic cluster analysis of a large data base of known crystallographic structures. Successful applications of these algorithms to the prediction of known protein conformations are presented. |
| Document Type: Article |
| Language: English |
| Reprint Address: TUFFERY, P (reprint author), UNIV PARIS 07, INSERM, U263, UNITE RECH BIOMATH & BIOSTAT, 2 PL JUSSIEU, F-75251 PARIS, FRANCE |
Addresses:
1. INST BIOL MOLEC, BIOCHIM THEOR LAB, CNRS, URA 77, F-75005 PARIS, FRANCE |
| Publisher: ADENINE PRESS INC, PO BOX 355/340, GUILDERLAND, NY 12084 |
| Subject Category: Biochemistry & Molecular Biology; Biophysics |
| IDS Number: FP816 |
| ISSN: 0739-1102 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |