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| GENETIC-ANALYSIS OF AUTOIMMUNE TYPE-1 DIABETES-MELLITUS IN MICE |
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| Author(s): TODD JA, AITMAN TJ, CORNALL RJ, GHOSH S, HALL JRS, HEARNE CM, KNIGHT AM, LOVE JM, MCALEER MA, PRINS JB, RODRIGUES N, LATHROP M, PRESSEY A, DELARATO NH, PETERSON LB, WICKER LS |
| Source: NATURE Volume: 351 Issue: 6327 Pages: 542-547 Published: JUN 13 1991 |
| Times Cited: 466 References: 50 |
| Abstract: Two genes, Idd-3 and Idd-4, that influence the onset of autoimmune type 1 diabetes in the nonobese diabetic mouse have been located on chromosomes 3 and 11, outside the chromosome 17 major histocompatibility complex. A genetic map of the mouse genome, analysed using the polymerase chain reaction, has been assembled specifically for the study. On the basis of comparative maps of the mouse and human genomes, the homologue of Idd-3 may reside on human chromosomes 1 or 4 and Idd-4 on chromosome 17. |
| Document Type: Article |
| Language: English |
| Reprint Address: TODD, JA (reprint author), JOHN RADCLIFFE HOSP, NUFFIELD DEPT SURG, OXFORD OX3 9DU, ENGLAND |
Addresses:
1. CLIN RES CTR, HARROW HA1 3UJ, MIDDX ENGLAND
2. CTR ETUD POLYMORPHISME HUMAINE, F-75010 PARIS, FRANCE
3. MERCK SHARP & DOHME LTD, DEPT CELLULAR & MOLEC PHARMACOL, RAHWAY, NJ 07065 USA
4. MERCK SHARP & DOHME LTD, AUTOIMMUNE DIS RES, RAHWAY, NJ 07065 USA |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: FR034 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |