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| COMPARING FUNCTIONAL (PET) IMAGES - THE ASSESSMENT OF SIGNIFICANT CHANGE |
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| Author(s): FRISTON KJ, FRITH CD, LIDDLE PF, FRACKOWIAK RSJ |
| Source: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM Volume: 11 Issue: 4 Pages: 690-699 Published: JUL 1991 |
| Times Cited: 1,177 References: 10 |
| Abstract: Statistical parametric maps (SPMs) are potentially powerful ways of localizing differences in regional cerebral activity. This potential is limited by uncertainties in assessing the significance of these maps. In this report, we describe an approach that may partially resolve this issue. A distinction is made between using SPMs as images of change significance and using them to identify foci of significant change. In the first case, the SPM can be reported nonselectively as a single mathematical object with its omnibus significance. Alternatively, the SPM constitutes a large number of repeated measures over the brain. To reject the null hypothesis, that no change has occurred at a specific location, a threshold adjustment must be made that accounts for the large number of comparisons made. This adjustment is shown to depend on the SPM's smoothness. Smoothness can be determined empirically and be used to calculate a threshold required to identify significant foci. The approach models the SPM as a stationary stochastic process. The theory and applications are illustrated using uniform phantom images and data from a verbal fluency activation study of four normal subjects. |
| Document Type: Article |
| Language: English |
| Reprint Address: FRISTON, KJ (reprint author), HAMMERSMITH HOSP, MRC, CYCLOTRON UNIT, DUCANE RD, LONDON W12 0HS, ENGLAND |
Addresses:
1. HAMMERSMITH HOSP, DEPT MED NEUROL, LONDON W12 0HS, ENGLAND
2. NORTHWICK PK HOSP & CLIN RES CTR, CLIN RES CTR, DIV PSYCHIAT, HARROW HA1 3UJ, MIDDX ENGLAND
3. WESTMINSTER MED SCH & HOSP, DEPT REHABIL PSYCHIAT, ACAD UNIT, LONDON SW1P 2AR, ENGLAND
4. CHARING CROSS HOSP & MED SCH, DEPT REHABIL PSYCHIAT, ACAD UNIT, LONDON, ENGLAND |
| Publisher: LIPPINCOTT-RAVEN PUBL, 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 |
| Subject Category: Endocrinology & Metabolism; Hematology; Neurosciences |
| IDS Number: FT182 |
| ISSN: 0271-678X |
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