| | |  | | | | Record from Web of Science® | | | | | | |
| TH2 CELLS IN SYSTEMIC AUTOIMMUNITY - INSIGHTS FROM ALLOGENEIC DISEASES AND CHEMICALLY-INDUCED AUTOIMMUNITY |
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| Author(s): GOLDMAN M, DRUET P, GLEICHMANN E |
| Source: IMMUNOLOGY TODAY Volume: 12 Issue: 7 Pages: 223-227 Published: JUL 1991 |
| Times Cited: 348 References: 57 |
| Abstract: Systemic autoimmune diseases can be induced experimentally in rodents by graft-versus-host or host-versus-graft reactions and by chemicals such as HgCl2, gold salts and D-penicillamine. These models share several features, such as production of anti-nuclear antibodies, immune glomerulonephritis, MHC class II hyperexpression on B cells, hyper-IgE, increased IL-4 activity and impairment of IL-2 production. This profile of cytokines suggests a central role for T(H)2-type cells in their pathogenesis. Here, Michel Goldman and colleagues review the data supporting this hypothesis and discuss the possible molecular bases for T-cell activation in chemically-induced systemic autoimmunity. |
| Document Type: Editorial Material |
| Language: English |
| Reprint Address: GOLDMAN, M (reprint author), UNIV LIBRE BRUXELLES, HOP ERASME, DEPT IMMUNOL, B-1050 BRUSSELS, BELGIUM |
Addresses:
1. HOP BOUCICAULT, INSERM, U28, F-75730 PARIS 15, FRANCE
2. UNIV DUSSELDORF, MED INST ENVIRONM HYG, DIV IMMUNOL, W-4000 DUSSELDORF 1, GERMANY |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Immunology |
| IDS Number: FU065 |
| ISSN: 0167-5699 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |