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| GENOMIC DIVERSITY AND ANTIGENIC VARIATION OF HIV-1 - LINKS BETWEEN PATHOGENESIS, EPIDEMIOLOGY AND VACCINE DEVELOPMENT |
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| Author(s): GOUDSMIT J, BACK NKT, NARA PL |
| Source: FASEB JOURNAL Volume: 5 Issue: 10 Pages: 2427-2436 Published: JUL 1991 |
| Times Cited: 68 References: 53 |
| Abstract: Recent analysis of primate lentivirus genomes (1) indicates that lentiviruses have infected primates for hundreds of years. The pathogenicity of such viruses may fluctuate due to the high evolution rate of some parts of the viral genome. Fixed nucleic acid substitutions in the gag gene appear to be caused by random fixation of selectively neutral mutants, whereas nonrandom fixation of selectively advantageous mutants, as has been observed for MHC molecules and serine protease inhibitors, appears to be operational for some hypervariable env gene regions. The former is characterized by an excess of silent mutations independent of the rate of change, the latter by an excess of nonsilent mutations. This latter type of selection may especially characterize the third variable region of the external HIV envelope (V3), which contains the principal neutralization domain. |
| Document Type: Review |
| Language: English |
| Reprint Address: GOUDSMIT, J (reprint author), UNIV AMSTERDAM, ACAD MED CTR, HUMAN RETROVIRUS LAB, MEIBERGDREEF 15, 1105 AZ AMSTERDAM, NETHERLANDS |
Addresses:
1. FREDERICK CANC RES DEV CTR, VIRUS BIOL SECT, FREDERICK, MD USA |
| Publisher: FEDERATION AMER SOC EXP BIOL, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 |
| Subject Category: Biochemistry & Molecular Biology; Biology; Cell Biology |
| IDS Number: FW087 |
| ISSN: 0892-6638 |
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