| ACTIN MICROFILAMENT DYNAMICS IN LOCOMOTING CELLS |
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| Author(s): THERIOT JA, MITCHISON TJ |
| Source: NATURE Volume: 352 Issue: 6331 Pages: 126-131 Published: JUL 11 1991 |
| Times Cited: 454 References: 41 |
| Abstract: The dynamic behaviour of actin filaments has been directly observed in living, motile cells using fluorescence photoactivation. In goldfish epithelial keratocytes, the actin microfilaments in the lamellipodium remain approximately fixed relative to the substrate as the cell moves over them, regardless of cell speed. The rate of turnover of actin subunits in the lamellipodium is remarkably rapid. Cell movement is directly and tightly coupled to the formation of new actin filaments at the leading edge. |
| Document Type: Article |
| Language: English |
| Reprint Address: THERIOT, JA (reprint author), UNIV CALIF SAN FRANCISCO, DEPT PHYSIOL & BIOPHYS, SAN FRANCISCO, CA 94143 USA |
Addresses:
1. UNIV CALIF SAN FRANCISCO, DEPT PHARMACOL, SAN FRANCISCO, CA 94143 USA |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: FW097 |
| ISSN: 0028-0836 |