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| FAMILIAL BREAST-OVARIAN CANCER LOCUS ON CHROMOSOME-17Q12-Q23 |
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| Author(s): NAROD SA, FEUNTEUN J, LYNCH HT, WATSON P, CONWAY T, LYNCH J, LENOIR GM |
| Source: LANCET Volume: 338 Issue: 8759 Pages: 82-83 Published: JUL 13 1991 |
| Times Cited: 451 References: 10 |
| Abstract: Familial breast cancer has been linked to the D17S74 locus on chromosome 17q. To confirm this finding and to investigate whether ovarian cancer is also linked to this locus, five large families with a hereditary predisposition to cancer of the breast and ovary were investigated. Three families were positive for linkage. For the largest family the lod score was 2.72. These findings suggest that the chromosomal region 17q12-q23, previously shown to contain a gene for early-onset breast cancer, is also associated with a proportion of hereditary ovarian cancers. |
| Document Type: Note |
| Language: English |
Addresses:
1. INT AGCY RES CANC, 150 COURS ALBERT THOMAS, F-69372 LYONS, FRANCE
2. MCGILL UNIV, DEPT ONCOL, MONTREAL H3G 1A4, QUEBEC CANADA
3. MCGILL UNIV, DEPT MED, MONTREAL H3G 1A4, QUEBEC CANADA
4. CREIGHTON UNIV, SCH MED, DEPT PREVENT MED, OMAHA, NE 68178 USA
5. MCGILL UNIV, CTR HUMAN GENET, MONTREAL H3G 1A4, QUEBEC CANADA
6. INST GUSTAVE ROUSSY, CNRS, UA 1158, F-94805 VILLEJUIF, FRANCE |
| Publisher: LANCET LTD, 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL |
| Subject Category: Medicine, General & Internal |
| IDS Number: FW161 |
| ISSN: 0140-6736 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |