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| CIRCULATING ICAM-1 ISOFORMS - DIAGNOSTIC PROSPECTS FOR INFLAMMATORY AND IMMUNE DISORDERS |
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| Author(s): SETH R, RAYMOND FD, MAKGOBA MW |
| Source: LANCET Volume: 338 Issue: 8759 Pages: 83-84 Published: JUL 13 1991 |
| Times Cited: 361 References: 10 |
| Abstract: Intercellular adhesion molecule-1 (ICAM-1, CD54) is an important early marker of immune activation and response. Evidence on its role has come from immunohistological staining of tissues, since no free circulating ICAM-1 has been detected. By means of monoclonal antibodies against ICAM-1 and a sensitive chemiluminescence technique, free circulating ICAM-1 was detected in serum from sixteen healthy young volunteers. The concentrations varied among the subjects. Non-denaturing gel separation methods showed that ICAM-1 circulates in at least three isoforms, the proportions of which also varied. These findings have important implications for the investigation, diagnosis, and therapeutic monitoring of various inflammatory, neoplastic, and immune disorders. |
| Document Type: Note |
| Language: English |
Addresses:
1. HAMMERSMITH HOSP, ROYAL POSTGRAD MED SCH, DEPT CHEM PATHOL, DIV MOLEC ENDOCRINOL, DU CANE RD, LONDON W12 0NN, ENGLAND |
| Publisher: LANCET LTD, 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL |
| Subject Category: Medicine, General & Internal |
| IDS Number: FW161 |
| ISSN: 0140-6736 |
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