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| LOCALIZATION OF THE AUTOSOMAL DOMINANT HLA-LINKED SPINOCEREBELLAR ATAXIA (SCAI) LOCUS, IN 2 KINDREDS, WITHIN AN 8-CM SUBREGION OF CHROMOSOME-6P |
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| Author(s): RANUM LPW, DUVICK LA, RICH SS, SCHUT LJ, LITT M, ORR HT |
| Source: AMERICAN JOURNAL OF HUMAN GENETICS Volume: 49 Issue: 1 Pages: 31-41 Published: JUL 1991 |
| Times Cited: 97 References: 33 |
| Abstract: Two large kindreds with HLA-linked, autosomal dominant spinocerebellar ataxia (SCA1) were examined with markers from chromosome 6p to determine the location of the SCA1 locus. Results of the three-point analysis between the markers HLA-A, SCA1, and F13A overwhelmingly favor the conclusion that SCA1 is located distal of HLA and proximal of F13A. In addition, our data strongly support the conclusion that SCA1 lies centromeric and genetically very close to the highly informative D6S89 marker within the 8-cM chromosomal segment flanked by the D6S88 and D6S89 markers. In the two kindreds, one recombinant was observed between D6S89 and SCA1, resulting in a recombination fraction of .014 between the two loci. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV MINNESOTA, DEPT LAB MED & PATHOL, BOX 206 UMHC, 420 DELAWARE ST SE, MINNEAPOLIS, MN 55455 USA
2. UNIV MINNESOTA, INST HUMAN GENET, MINNEAPOLIS, MN 55455 USA
3. VET ADM MED CTR, MINNEAPOLIS, MN 55417 USA
4. OREGON HLTH SCI UNIV, DEPT BIOCHEM, PORTLAND, OR 97201 USA
5. OREGON HLTH SCI UNIV, DEPT MED GENET, PORTLAND, OR 97201 USA |
| Publisher: UNIV CHICAGO PRESS, 5720 S WOODLAWN AVE, CHICAGO, IL 60637 |
| Subject Category: Genetics & Heredity |
| IDS Number: FW511 |
| ISSN: 0002-9297 |
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