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| MAJOR ALTERATION OF THE PATHOLOGICAL PHENOTYPE IN GAMMA-IRRADIATED MDX SOLEUS MUSCLES |
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| Author(s): WELLER B, KARPATI G, LEHNERT S, CARPENTER S |
| Source: JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY Volume: 50 Issue: 4 Pages: 419-431 Published: JUL 1991 |
| Times Cited: 25 References: 28 |
| Abstract: Two thousand rads of gamma irradiation delivered to the lower legs of ten day old normal and x-chromosome linked muscular dystrophy (mdx) mice caused significant inhibition of tibial bone and soleus muscle fiber growth. In the irradiated mdx solei, there was a major loss of muscle fibers, lack of central nucleation, and some endomysial fibrosis. These features were caused by a failure of regeneration of muscle fibers due to impaired proliferative capacity of satellite cells. Gamma irradiation transforms the late pathological phenotype of mdx muscles, so that in one major aspect (muscle fiber loss) they resemble muscles in Duchenne muscular dystrophy. However, extensive endomysial fibrosis which is another characteristic feature of Duchenne muscular dystrophy did not develop. This experimental model could be useful for the functional investigation of possible beneficial effects of therapeutic interventions in mdx dystrophy. |
| Document Type: Article |
| Language: English |
Addresses:
1. MONTREAL NEUROL HOSP & INST, 3801 UNIV ST, MONTREAL H3A 2B4, QUEBEC CANADA
2. MCGILL UNIV, MONTREAL NEUROL INST, NEUROMUSCULAR RES GRP, MONTREAL H3A 2T5, QUEBEC CANADA
3. MCGILL UNIV, DEPT RADIAT ONCOL, MONTREAL H3A 2T5, QUEBEC CANADA |
| Publisher: AMER ASSN NEUROPATHOLOGISTS INC, 1041 NEW HAMPSHIRE ST, LAWRENCE, KS 66044 |
| Subject Category: Clinical Neurology; Neurosciences; Pathology |
| IDS Number: FW806 |
| ISSN: 0022-3069 |
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