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| EVIDENCE FOR THE EFFECTS OF A SUPERANTIGEN IN RHEUMATOID-ARTHRITIS |
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| Author(s): PALIARD X, WEST SG, LAFFERTY JA, CLEMENTS JR, KAPPLER JW, MARRACK P, KOTZIN BL |
| Source: SCIENCE Volume: 253 Issue: 5017 Pages: 325-329 Published: JUL 19 1991 |
| Times Cited: 599 References: 45 |
| Abstract: While studying the alpha-beta T cell receptor repertoire in rheumatoid arthritis (RA) patients, we found that the frequency of V-beta-14+ T cells was significantly higher in the synovial fluid of affected joints than in the peripheral blood. In fact, V-beta-14+ T cells were virtually undetectable in the peripheral blood of a majority of these RA patients. beta-chain sequences indicated that one or a few clones dominated the V-beta-14+ population in the synovial fluid of individual RA patients, whereas oligoclonality was less marked for other V-beta's and for V-beta-14 in other types of inflammatory arthritis. These results implicate V-beta-14-bearing T cells in the pathology of RA. They also suggest that the etiology of RA may involve initial activation of V-beta-14+ T cells by a V-beta-14-specific superantigen with subsequent recruitment of a few activated autoreactive V-beta-14+ T cell clones to the joints while the majority of other V-beta-14+ T cells disappear. |
| Document Type: Article |
| Language: English |
Addresses:
1. HOWARD HUGHES MED INST, DENVER, CO 80206 USA
2. NATL JEWISH CTR IMMUNOL & RESP MED, DEPT MED, DENVER, CO 80206 USA
3. FITZSIMONS ARMY MED CTR, DEPT MED, AURORA, CO 80045 USA
4. NATL JEWISH CTR IMMUNOL & RESP MED, DEPT PEDIAT, DENVER, CO 80206 USA
5. UNIV COLORADO, HLTH SCI CTR, DEPT MICROBIOL IMMUNOL, DENVER, CO 80262 USA
6. UNIV COLORADO, HLTH SCI CTR, DEPT MED, DENVER, CO 80262 USA
7. UNIV COLORADO, HLTH SCI CTR, DEPT BIOCHEM, DENVER, CO 80262 USA
8. UNIV COLORADO, HLTH SCI CTR, DEPT BIOPHYS, DENVER, CO 80262 USA
9. UNIV COLORADO, HLTH SCI CTR, DEPT GENET, DENVER, CO 80262 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: FX224 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |