| | |  | | | | Record from Web of Science® | | | | | | |
| THE POLYPEPTIDE ENCODED BY THE CDNA FOR HUMAN CELL-SURFACE ANTIGEN FAS CAN MEDIATE APOPTOSIS |
|
|
| Author(s): ITOH N, YONEHARA S, ISHII A, YONEHARA M, MIZUSHIMA S, SAMESHIMA M, HASE A, SETO Y, NAGATA S |
| Source: CELL Volume: 66 Issue: 2 Pages: 233-243 Published: JUL 26 1991 |
| Times Cited: 2,402 References: 49 |
| Abstract: Mouse anti-Fas monoclonal antibody has a cytolytic activity on human cells that express the antigen. Complementary DNAs encoding the cell surface antigen Fas were isolated from a cDNA library of human T cell lymphoma KT-3 cells. The nucleotide sequence of the cDNAs revealed that the molecule coding for the Fas antigen determinant is a 319 amino acid polypeptide (M(r) 36,000) with a single transmembrane domain. The extracellular domain is rich in cysteine residue, and shows a similarity to that of human tumor necrosis factor receptors, human nerve growth factor receptor, and human B cell antigen CD40. Murine WR19L cells or L929 cells transformed with the human Fas antigen cDNA were killed by the anti-Fas antibody in the process known as apoptosis. |
| Document Type: Article |
| Language: English |
| Reprint Address: ITOH, N (reprint author), OSAKA BIOSCI INST, 6-2-4 FURUEDAI, SUITA, OSAKA 565 JAPAN |
Addresses:
1. TOKYO METROPOLITAN INST MED SCI, BUNKYO KU, TOKYO 113, JAPAN
2. OSAKA CITY INST PUBL HLTH & ENVIRONM SCI, TENNOJI KU, OSAKA 543, JAPAN |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: FY712 |
| ISSN: 0092-8674 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |