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| RENAL CYST FORMATION AND MULTIFOCAL NEOPLASIA IN TRANSGENIC MICE CARRYING THE SIMIAN VIRUS-40 EARLY REGION |
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| Author(s): KELLEY KA, AGARWAL N, REEDERS S, HERRUP K |
| Source: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 2 Issue: 1 Pages: 84-97 Published: JUL 1991 |
| Times Cited: 44 References: 43 |
| Abstract: Simian virus 40 early region transgenic mice develop characteristic pathological abnormalities of the brain, kidney, and thymus, due to expression of large-T antigen. Earlier studies have indicated that the most consistent effect of large-T antigen expression is the formation of choroid plexus papillomas in the brain and that thymic hyperplasia and various kidney abnormalities are less frequently observed. The renal lesions reportedly consist of numerous glomerular abnormalities and tubular proliferation. Surprisingly, an analysis of 21 simian virus 40 early region transgenic mice, which were produced for this study, revealed a much higher incidence of polycystic kidney disease as well as earlier development of T-antigen-induced abnormalities. In marked contrast to earlier observations, there is an apparent reduction in the glomerular number in the affected kidneys, whereas the remaining glomeruli appear normal. The most striking feature of the T-antigen-induced renal abnormalities was extensive hyperplasia of tubular epithelial cells which was most marked in the distal tubules; all tubule segments are involved in the most severely affected animals. In most cases, cysts lined with hyperplastic epithelium were observed and papillary structures protruding from the cyst lining were evident. Multiple areas of focal neoplasia were apparent, and, in the most severely affected animals, there were areas in which tumor had replaced normal renal parenchyma. These results strongly suggest that T-antigen-induced renal cyst and tumor formation are part of the same pathological process which is initially manifested as tubular epithelial hyperplasia. |
| Document Type: Article |
| Language: English |
| Reprint Address: KELLEY, KA (reprint author), CUNY MT SINAI SCH MED, ARTHUR M FISHBERG RES CTR NEUROBIOL, BOX 1065, 1 GUSTAVE LEVY PL, NEW YORK, NY 10029 USA |
Addresses:
1. UNIV TEXAS, HLTH SCI CTR, DEPT PATHOL, SAN ANTONIO, TX 78284 USA
2. EK SHRIVER CTR, DEPT DEV NEUROBIOL, WALTHAM, MA USA |
| Publisher: WILLIAMS & WILKINS, 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 |
| Subject Category: Urology & Nephrology |
| IDS Number: FZ094 |
| ISSN: 1046-6673 |
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