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| IDENTIFICATION OF THE SKELETAL REMAINS OF A MURDER VICTIM BY DNA ANALYSIS |
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| Author(s): HAGELBERG E, GRAY IC, JEFFREYS AJ |
| Source: NATURE Volume: 352 Issue: 6334 Pages: 427-429 Published: AUG 1 1991 |
| Times Cited: 164 References: 13 |
| Abstract: THERE is considerable anthropological and forensic interest in the possibility of DNA typing skeletal remains. Trace amounts of DNA can be recovered even from 5,500-year-old bones and multicopy human mitochondrial DNA sequences can frequently be amplified from such DNA using the polymerase chain reaction (PCR) 1,2. But given the sensitivity of PCR, it is very difficult to exclude contaminating material. We now report the successful identification of the 8-year-old skeletal remains of a murder victim, by comparative typing of nuclear microsatellite markers 3-5 in the remains and in the presumptive parents of the victim. This analysis establishes the authenticity of the bone DNA and the feasibility of bone DNA typing in forensic investigations. |
| Document Type: Article |
| Language: English |
| Reprint Address: HAGELBERG, E (reprint author), UNIV OXFORD, JOHN RADCLIFFE HOSP, INST MOLEC MED, MRC, MOLEC HAEMATOL UNIT, OXFORD OX3 9DU, ENGLAND |
Addresses:
1. UNIV LEICESTER, DEPT GENET, LEICESTER LE1 7RH, ENGLAND |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: FZ346 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |