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| THE APOLIPOPROTEIN-E POLYMORPHISM - A COMPARISON OF ALLELE FREQUENCIES AND EFFECTS IN 9 POPULATIONS |
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| Author(s): HALLMAN DM, BOERWINKLE E, SAHA N, SANDHOLZER C, MENZEL HJ, CSAZAR A, UTERMANN G |
| Source: AMERICAN JOURNAL OF HUMAN GENETICS Volume: 49 Issue: 2 Pages: 338-349 Published: AUG 1991 |
| Times Cited: 377 References: 56 |
| Abstract: Application of uniform methods for measuring the apolipoprotein (apo) E polymorphism and plasma cholesterol levels in nine populations (Tyrolean, Sudanese, Indian, Chinese, Japanese, Hungarian, Icelandic, Finnish, and Malay) revealed significant heterogeneity among them in apo E type frequencies and mean cholesterol levels. The major apo E types in all populations were E3/2 (frequency range from 7.0% in Indians to 16.9% in Malays), E3/3 (frequency range from 39.8% in Sudanese to 72.1% in Japanese), and E3/4 (frequency range from 11.3% in Japanese to 35.9% in Sudanese). Mean cholesterol levels ranged from 144.2 mg/dl in the Sudanese to 228.5 mg/dl in the Icelandics. Two-way analysis of variance of the effect of population and apo E type on cholesterol levels showed no significant interaction effect, indicating that the effects of apo E type on cholesterol levels do not differ significantly among the populations. The overall average excess for the epsilon-2 allele was - 14.12 mg/dl (range - 31.63 to - 8.82 mg/dl); for the epsilon-3 allele, 0.04 mg/dl (range - 1.87 to 1.58 mg/dl; and for the epsilon-4 allele, 8.14 mg/dl (range - 1.71 to 13.31 mg/dl). Despite the apparent heterogeneity in these values, especially for the epsilon-4 allele, comparison of the average excesses by a method of repeated sampling with random permutations revealed no significant difference in effects among populations. These data indicate that a given apo E allele acts in a relatively uniform manner in different populations despite differences in genetic background and environmental factors. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV TEXAS, HLTH SCI CTR, CTR DEMOG & POPULAT GENET, HOUSTON, TX 77225 USA
2. NATL UNIV SINGAPORE HOSP, DIV GENET, SINGAPORE, SINGAPORE
3. UNIV INNSBRUCK, INST MED BIOL & HUMAN GENET, A-6020 INNSBRUCK, AUSTRIA |
| Publisher: UNIV CHICAGO PRESS, 5720 S WOODLAWN AVE, CHICAGO, IL 60637 |
| Subject Category: Genetics & Heredity |
| IDS Number: GA866 |
| ISSN: 0002-9297 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |