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| A DIRECT REPEAT IN THE CELLULAR RETINOL-BINDING PROTEIN TYPE-II GENE CONFERS DIFFERENTIAL REGULATION BY RXR AND RAR |
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| Author(s): MANGELSDORF DJ, UMESONO K, KLIEWER SA, BORGMEYER U, ONG ES, EVANS RM |
| Source: CELL Volume: 66 Issue: 3 Pages: 555-561 Published: AUG 9 1991 |
| Times Cited: 562 References: 29 |
| Abstract: The vitamin A derivative retinoic acid exerts its effects on transcription through two distinct classes of nuclear receptors, the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR. This regulation is conferred through a specific cis element in the CRBPII promoter that contains five nearly perfect tandem repeats of the sequence AGGTCA spaced by a single nucleotide. The discovery of this new RX response element provides a means for distinguishing between the two retinoid receptor systems and suggests that an RXR-mediated pathway exists for modulating vitamin A metabolism. |
| Document Type: Article |
| Language: English |
| Reprint Address: MANGELSDORF, DJ (reprint author), HOWARD HUGHES MED INST, LA JOLLA, CA 92186 USA |
Addresses:
1. SALK INST BIOL STUDIES, LA JOLLA, CA 92186 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: GA941 |
| ISSN: 0092-8674 |
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