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| NONRANDOM ASSOCIATION BETWEEN DNA MARKERS AND HUNTINGTON DISEASE LOCUS IN THE ITALIAN POPULATION |
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| Author(s): NOVELLETTO A, MANDICH P, BELLONE E, MALASPINA P, VIVONA G, AJMAR F, FRONTALI M |
| Source: AMERICAN JOURNAL OF MEDICAL GENETICS Volume: 40 Issue: 3 Pages: 374-376 Published: SEP 1 1991 |
| Times Cited: 9 References: 21 |
| Abstract: A group of Huntington disease (HD) families of Italian ancestry was analyzed for 11 RFLPs from genetic loci mapped in 4p16 and genetically linked to the HD gene. We found a statistically significant difference of allele distributions in HD vs normal chromosomes for loci D4S10, D4S127, and D4S43. This observation increases the number of loci in linkage disequilibrium with HD. However, the amount of disequilibrium does not allow either a finer localization of the HD gene or a substantial improvement in risk calculations. |
| Document Type: Article |
| Language: English |
| Reprint Address: NOVELLETTO, A (reprint author), UNIV TOR VERGATA, DIPARTIMENTO BIOL, VIA O RAIMONDO, I-00173 ROME, ITALY |
Addresses:
1. UNIV TOR VERGATA, DIPARTIMENTO SANITA & BIOL CELLULARE, ROME, ITALY
2. CNR, IST MED SPERMIMENTALE, ROME, ITALY
3. UNIV GENOA, IST SCI MED INTERNA, CATTEDRA GENET MED, I-16126 GENOA, ITALY |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 |
| Subject Category: Genetics & Heredity |
| IDS Number: GB575 |
| ISSN: 0148-7299 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |