| | |  | | | | Record from Web of Science® | | | | | | |
| THE MSH-LIKE HOMEOBOX GENES DEFINE DOMAINS IN THE DEVELOPING VERTEBRATE EYE |
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| Author(s): MONAGHAN AP, DAVIDSON DR, SIME C, GRAHAM E, BALDOCK R, BHATTACHARYA SS, HILL RE |
| Source: DEVELOPMENT Volume: 112 Issue: 4 Pages: 1053-1061 Published: AUG 1991 |
| Times Cited: 191 References: 37 |
| Abstract: The mouse Hox-7.1 gene has previously been shown to be related to the Drosophila Msh homeobox-containing gene. Here we report the isolation of a new member of this family which resides at an unlinked chromosomal location and has been designated Hox-8.1. Both Hox-7.1 and Hox-8.1 are expressed in the mouse embryo during the early stages of eye development in a distinct spatial and temporal relationship. Hox-8.1 is expressed in the surface ectoderm and in the optic vesicle before invagination occurs in regions corresponding to the prospective corneal epithelium and neural retina, respectively. Hox-7.1 is expressed after formation of the optic cup, marking the domain that will give rise to the ciliary body. The activity of these genes indicates that the inner layer of the optic cup is differentiated into three distinct compartments before overt cellular differentiation occurs. Our results suggest that these genes are involved in defining the region that gives rise to the inner layer of the optic cup and in patterning this tissue to define the iris, ciliary body and retina. |
| Document Type: Article |
| Language: English |
| Reprint Address: MONAGHAN, AP (reprint author), WESTERN GEN HOSP, MRC, HUMAN GENET UNIT, CREWE RD, EDINBURGH EH4 2XU, MIDLOTHIAN SCOTLAND |
Addresses:
1. UNIV NEWCASTLE UPON TYNE, DEPT HUMAN GENET, NEWCASTLE UPON TYNE NE2 4AA, ENGLAND |
| Publisher: COMPANY OF BIOLOGISTS LTD, BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE, CAMBS, ENGLAND CB4 4DL |
| Subject Category: Developmental Biology |
| IDS Number: GB602 |
| ISSN: 0950-1991 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |