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| SERUM LEVELS OF CIRCULATING INTERCELLULAR-ADHESION MOLECULE-1 IN HUMAN-MALIGNANT MELANOMA |
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| Author(s): HARNING R, MAINOLFI E, BYSTRYN JC, HENN M, MERLUZZI VJ, ROTHLEIN R |
| Source: CANCER RESEARCH Volume: 51 Issue: 18 Pages: 5003-5005 Published: SEP 15 1991 |
| Times Cited: 173 References: 23 |
| Abstract: Current reports have suggested a role for intracellular adhesion molecule 1 (ICAM-1) in the progression of human malignant melanoma and other cancers. Stage I, II, and III patients with histologically diagnosed malignant melanoma had significantly increased serum levels of circulating ICAM-1 (cICAM-1) and a striking increase in the incidence of positive sera. In Stage II and III patients, the level of cICAM-1 was inversely correlated with survival. Patients with elevated levels of serum cICAM-1 (greater than 2 SD units above control mean) had a significantly shorter mean survival. We suggest that elevated levels of serum cICAM-1 may be of diagnostic and prognostic importance in patients with malignant cutaneous melanoma. |
| Document Type: Note |
| Language: English |
| Reprint Address: HARNING, R (reprint author), BOEHRINGER INGELHEIM PHARMACEUT, DEPT IMMUNOL, 90 E RIDGE, PO 368, RIDGEFIELD, CT 06877 USA |
Addresses:
1. NYU MED CTR, DEPT DERMATOL, NEW YORK, NY 10016 USA |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: GE303 |
| ISSN: 0008-5472 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |