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| THE HIV-1 REV PROTEIN - PROTOTYPE OF A NOVEL CLASS OF EUKARYOTIC POSTTRANSCRIPTIONAL REGULATORS |
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| Author(s): CULLEN BR, MALIM MH |
| Source: TRENDS IN BIOCHEMICAL SCIENCES Volume: 16 Issue: 9 Pages: 346-350 Published: SEP 1991 |
| Times Cited: 83 References: 32 |
| Abstract: Complex retroviruses, including Human Immunodeficiency Virus Type 1 (HIV-1), are characterized by the ordered temporal expression of the various viral gene products in infected cells. This effect is mediated by a novel class of RNA-sequence-specific regulatory proteins typified by the Rev trans-activator of HIV-1. Evidence suggests that Rev regulates HIV-1 gene expression by intervening in the normal pathway of eukaryotic MRNA processing and transport. |
| Document Type: Review |
| Language: English |
| Reprint Address: CULLEN, BR (reprint author), DUKE UNIV, MED CTR, HOWARD HUGHES MED INST, DEPT MICROBIOL & IMMUNOL, DURHAM, NC 27710 USA |
Addresses:
1. DUKE UNIV, MED CTR, DEPT MED, DURHAM, NC 27710 USA |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: GE901 |
| ISSN: 0968-0004 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |