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| HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION IN THE UNITED-STATES AIR-FORCE - SEROCONVERSIONS, CLINICAL STAGING, AND ASSESSMENT OF A T HELPER-CELL FUNCTIONAL ASSAY TO PREDICT CHANGE IN CD4+ T-CELL COUNTS |
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| Author(s): LUCEY DR, MELCHER GP, HENDRIX CW, ZAJAC RA, GOETZ DW, BUTZIN CA, CLERICI M, WARNER RD, ABBADESSA S, HALL K, JASO R, WOOLFORD B, MILLER S, STOCKS NI, SALINAS CM, WOLFE WH, SHEARER GM, BOSWELL RN |
| Source: JOURNAL OF INFECTIOUS DISEASES Volume: 164 Issue: 4 Pages: 631-637 Published: OCT 1991 |
| Times Cited: 83 References: 53 |
| Abstract: As of January 1990, 933 persons with human immunodeficiency virus type 1 (HIV-1) infection were clinically evaluated at Wilford Hall US Air Force (USAF) Medical Center. The Walter Reed HIV staging system was used in these evaluations to describe disease status and progression. Most persons were diagnosed through mandatory HIV testing in the USAF and were asymptomatic at the time of diagnosis. As of May 1990, 161 HIV-positive seroconverters (estimated overall seroconversion rate of 0.156/1000 person-years between 30 June 1988 and 1 July 1990) had been identified among active-duty USAF personnel, as they had previously tested negative for antibody to HIV. Men constitute 95% of the USAF HIV-positive population. An in vitro T helper cell functional assay was assessed to predict rate of CD4+ T cell decline over the subsequent year (mean, 15 months) in patients with > 200 CD4+ T cells/mm3. This assay may prove useful for prognostication and comparisons of patients in clinical trials of anti-HIV interventions. |
| Document Type: Article |
| Language: English |
Addresses:
1. WILFORD HALL USAF MED CTR, DEPT MED, LACKLAND AFB, TX 78236 USA
2. WILFORD HALL USAF MED CTR, CLIN INVEST DIRECTORATE, LACKLAND AFB, TX 78236 USA
3. ARMSTRONG LAB, EPIDEMIOL RES DIV, DIV HUMAN SYST, BROOKS AFB, TX USA
4. NCI, EXPTL IMMUNOL BRANCH, BETHESDA, MD 20892 USA |
| Publisher: UNIV CHICAGO PRESS, 5720 S WOODLAWN AVE, CHICAGO, IL 60637 |
| Subject Category: Infectious Diseases |
| IDS Number: GF805 |
| ISSN: 0022-1899 |
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