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HOX GENE ACTIVATION BY RETINOIC ACID
Author(s): BONCINELLI E, SIMEONE A, ACAMPORA D, MAVILIO F
Source: TRENDS IN GENETICS    Volume: 7    Issue: 10    Pages: 329-334    Published: OCT 1991  
Times Cited: 172     References: 38     
Abstract: Vertebrate homeobox genes of the Hox family are, like Drosophila homeotic genes, organized in gene clusters and show a strict correspondence, or collinearity, between the order of the genes (3' to 5') within the chromosomal cluster and that of their expression domains (anterior to posterior) in the embryo. Recent data obtained from embryonal carcinoma cells induced to differentiate by retinoic acid cast some light on the molecular mechanisms underlying the collinear expression of the Hox genes.
Document Type: Review
Language: English
Reprint Address: BONCINELLI, E (reprint author), CNR, INT INST GENET & BIOPHYS, VIA MARCONI 10, I-80125 NAPLES, ITALY
Addresses:
1. IST SCI HS RAFFAELE, I-20132 MILAN, ITALY
Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB
Subject Category: Genetics & Heredity
IDS Number: GG258
ISSN: 0168-9525
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