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| NEOVASCULARIZATION IS ASSOCIATED WITH A SWITCH TO THE EXPORT OF BFGF IN THE MULTISTEP DEVELOPMENT OF FIBROSARCOMA |
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| Author(s): KANDEL J, BOSSYWETZEL E, RADVANYI F, KLAGSBRUN M, FOLKMAN J, HANAHAN D |
| Source: CELL Volume: 66 Issue: 6 Pages: 1095-1104 Published: SEP 20 1991 |
| Times Cited: 449 References: 48 |
| Abstract: In a transgenic mouse model, dermal fibrosarcomas develop in a pathway comprised of at least three stages: mild fibromatosis, aggressive fibromatosis, and fibrosarcoma. The latter two stages are highly vascularized when compared with both the normal dermis and the initial mild lesion. Analysis of cell cultures derived from biopsies of these lesions has revealed that basic fibroblast growth factor (bFGF) is synthesized in all three stages and in normal dermal fibroblasts derived from the same mice. Unexpectedly, there is a change in the localization of bFGF from its normal cell-associated state to extracellular release in the latter two stages, which is concomitant both with the neovascularization seen in vivo and with the tumorigenicity of these cell lines. Thus, in this multistep tumorigenesis pathway there appears to be a discrete switch to the angiogenic phenotype that correlates with the export of bFGF, a known angiogenic factor. |
| Document Type: Article |
| Language: English |
| Reprint Address: KANDEL, J (reprint author), HARVARD UNIV, CHILDRENS HOSP, SCH MED, DEPT SURG, BOSTON, MA 02115 USA |
Addresses:
1. HARVARD UNIV, SCH MED, DEPT SURG, BOSTON, MA 02115 USA
2. HARVARD UNIV, SCH MED, DEPT BIOL CHEM, BOSTON, MA 02115 USA
3. HARVARD UNIV, SCH MED, DEPT ANAT & CELLULAR BIOL, BOSTON, MA 02115 USA
4. UNIV CALIF SAN FRANCISCO, HORMONE RES INST, DEPT BIOCHEM & BIOPHYS, SAN FRANCISCO, CA 94143 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: GG552 |
| ISSN: 0092-8674 |
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