| | |  | | | | Record from Web of Science® | | | | | | |
| TRANSFORMING GROWTH-FACTOR -BETA - AN IMPORTANT MEDIATOR OF IMMUNOREGULATION |
|
|
| Author(s): KEHRL JH |
| Source: INTERNATIONAL JOURNAL OF CELL CLONING Volume: 9 Issue: 5 Pages: 438-450 Published: SEP 1991 |
| Times Cited: 82 References: 66 |
| Abstract: Transforming growth factor-beta (TGF-beta) is synthesized and secreted by a wide variety of cells, including cells of the immune system. Lymphocytes and monocytes possess high affinity TGF-beta-receptors and the addition of TGF-beta to in vitro cell cultures results in significant modulation of immune function. TGF-beta-inhibits the proliferation of thymocytes, T cells, B cells, and natural killer cells. Additionally, it inhibits certain differentiative functions of lymphocytes including a marked inhibition of immunoglobulin production by human B lymphocytes. TGF-beta has dichotomous actions on monocytes. It is a potent chemoattractant for monocytes and induces interleukin 1 mRNA expression while inhibiting generation of reactive oxygen intermediates and monocyte killing. Evidence is accumulating that TGF-beta-regulates immune function in vivo and that overproduction of TGF-beta may be associated with immunosuppression. |
| Document Type: Review |
| Language: English |
| Reprint Address: KEHRL, JH (reprint author), NIAID, IMMUNOREGULAT LAB, BLDG 10, ROOM 11B-13, BETHESDA, MD 20892 USA |
| Publisher: ALPHAMED PRESS, 4100 S KETTERING BLVD, DAYTON, OH 45439-2092 |
| Subject Category: Biotechnology & Applied Microbiology |
| IDS Number: GH260 |
| ISSN: 0737-1454 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |