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| GENETIC-MAPPING OF A GENE CAUSING HYPERTENSION IN THE STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RAT |
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| Author(s): JACOB HJ, LINDPAINTNER K, LINCOLN SE, KUSUMI K, BUNKER RK, MAO YP, GANTEN D, DZAU VJ, LANDER ES |
| Source: CELL Volume: 67 Issue: 1 Pages: 213-224 Published: OCT 4 1991 |
| Times Cited: 615 References: 54 |
| Abstract: The stroke-prone spontaneously hypertensive rat (SHRSP) is a well-characterized model for primary hypertension in humans. High blood pressure in SHRSP shows polygenic inheritance, but none of the loci responsible have previously been identified. To locate genes controlling this quantitative trait, we mapped a large collection of DNA polymorphisms in a cross between SHRSP and the normotensive WKY strain. Here we report strong genetic evidence that a gene, Bp1, having a major effect on blood pressure maps to rat chromosome 10 with a LOD score of 5.10 and is closely linked to the rat gene encoding angiotensin-converting enzyme (ACE), an enzyme that plays a major role in blood pressure homeostasis and is an important target of anti-hypertensive drugs. We also find significant, albeit weaker, linkage to a locus, Bp2, on chromosome 18. We discuss the implications of genetic dissection of quantitative disease-related phenotypes in mammals. |
| Document Type: Article |
| Language: English |
| Reprint Address: JACOB, HJ (reprint author), WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA 02142 USA |
Addresses:
1. UNIV HEIDELBERG, GERMAN INST HIGH BLOOD PRESSURE RES, W-6900 HEIDELBERG, GERMANY
2. CTR MOLEC MED, BERLIN, GERMANY
3. STANFORD UNIV, MED CTR, DIV CARDIOL, STANFORD, CA 94305 USA
4. UNIV HEIDELBERG, DEPT PHARMACOL, W-6900 HEIDELBERG, GERMANY
5. HARVARD UNIV, CHILDRENS HOSP, DEPT CARDIOL, BOSTON, MA 02115 USA
6. HARVARD UNIV, BRIGHAM & WOMENS HOSP, DIV CARDIOL, BOSTON, MA 02115 USA
7. MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: GJ320 |
| ISSN: 0092-8674 |
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