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| THE MELANIE PROJECT - FROM A BIOPSY TO AUTOMATIC PROTEIN MAP INTERPRETATION BY COMPUTER |
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| Author(s): APPEL RD, HOCHSTRASSER DF, FUNK M, VARGAS JR, PELLEGRINI C, MULLER AF, SCHERRER JR |
| Source: ELECTROPHORESIS Volume: 12 Issue: 10 Pages: 722-735 Published: OCT 1991 |
| Times Cited: 119 References: 37 |
| Abstract: The goals of the MELANIE project are to determine if disease-associated patterns can be detected in high resolution two-dimensional polyacrylamide gel electrophoresis (HR 2D-PAGE) images and if a diagnosis can be established automatically by computer. The ELSIE/MELANIE system is a set of computer programs which automatically detect, quantify, and compare protein spots shown on HR 2D-PAGE images. Classification programs help the physician to find disease-associated patterns from a given set of two-dimensional gel electrophoresis images and to form diagnostic rules. Prototype expert systems that use these rules to establish a diagnosis from new HR 2D-PAGE images have been developed. They successfully diagnosed cirrhosis of the liver and were able to distinguish a variety of cancer types from biopsies known to be cancerous. |
| Document Type: Article |
| Language: English |
| Reprint Address: APPEL, RD (reprint author), HOP CANTONAL GENEVA, CTR INFORMAT HOSP, UNITE IMAGERIE NUMER, 24 RUE MICHELIDUCREST, CH-1211 GENEVA 4, SWITZERLAND |
Addresses:
1. HOP CANTONAL GENEVA, DEPT MED, MED CLIN, CH-1211 GENEVA 4, SWITZERLAND
2. UNIV GENEVA, DEPT COMP SCI, CH-1211 GENEVA 4, SWITZERLAND |
| Publisher: VCH PUBLISHERS INC, 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 |
| Subject Category: Biochemical Research Methods; Chemistry, Analytical |
| IDS Number: GM526 |
| ISSN: 0173-0835 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |