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| L-ARGININE ABROGATES SALT-SENSITIVE HYPERTENSION IN DAHL RAPP RATS |
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| Author(s): CHEN PY, SANDERS PW |
| Source: JOURNAL OF CLINICAL INVESTIGATION Volume: 88 Issue: 5 Pages: 1559-1567 Published: NOV 1991 |
| Times Cited: 344 References: 31 |
| Abstract: This study examined the contribution of nitric oxide (NO) to the susceptibility or resistance to the hypertensive effects of high sodium chloride (8.0% NaCl) intake in young Dahl/Rapp salt-sensitive (SS/Jr) and salt-resistant (SR/Jr) rats. Using N(G)-monomethyl-L-arginine (L-NMMA) as a probe for NO production in vivo, we found that increasing dietary sodium choride increased NO activity in salt-resistant rats, but not in salt-sensitive rats. Exogenous L-arginine, the substrate for NO synthesis, decreased blood pressure to normotensive levels in salt-sensitive rats made hypertensive for 2 wk from 8.0% NaCl chow. D-Arginine had no effect on blood pressure of these rats and L-arginine did not change blood pressure of salt-resistant rats. Intraperitoneal injections Of L-arginine and its precursor, L-citrulline, and oral L-arginine, but not D-arginine, prevented the increase in blood pressure in salt-sensitive rats on the high salt chow over 2 wk of observation. In contrast, L-arginine did not alter the development of hypertension in spontaneously hypertensive rats. Mean urinary cGMP levels were higher in salt-sensitive rats on oral L-arginine than salt-sensitive rats on D-arginine. Infusion of L-NMMA acutely decreased, whereas intravenous L-arginine rapidly increased, urinary cGMP in both groups. L-Arginine and L-citrulline increased production of NO and prevented salt-sensitive hypertension in Dahl/Rapp rats. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV ALABAMA, DEPT MED, DIV NEPHROL, 6TH FLOOR, ZEIGLER BLDG, BIRMINGHAM, AL 35294 USA
2. UNIV ALABAMA, NEPHROL RES & TRAINING CTR, BIRMINGHAM, AL 35294 USA |
| Publisher: ROCKEFELLER UNIV PRESS, 222 E 70TH STREET, NEW YORK, NY 10021 |
| Subject Category: Medicine, Research & Experimental |
| IDS Number: GN727 |
| ISSN: 0021-9738 |
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