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MOLECULAR-CLONING AND CHARACTERIZATION OF THE RAT NMDA RECEPTOR
Author(s): MORIYOSHI K, MASU M, ISHII T, SHIGEMOTO R, MIZUNO N, NAKANISHI S
Source: NATURE    Volume: 354    Issue: 6348    Pages: 31-37    Published: NOV 7 1991  
Times Cited: 1,486     References: 44     
Abstract: A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum.
Document Type: Article
Language: English
Reprint Address: MORIYOSHI, K (reprint author), KYOTO UNIV, FAC MED, INST IMMUNOL, KYOTO 606, JAPAN
Addresses:
1. KYOTO UNIV, DEPT MORPHOL BRAIN SCI, KYOTO 606, JAPAN
Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF
Subject Category: Multidisciplinary Sciences
IDS Number: GN829
ISSN: 0028-0836
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