| | |  | | | | Record from Web of Science® | | | | | | |
| DROSOPHILA-ABL AND GENETIC REDUNDANCY IN SIGNAL TRANSDUCTION |
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| Author(s): HOFFMANN FM |
| Source: TRENDS IN GENETICS Volume: 7 Issue: 11-12 Pages: 351-356 Published: NOV-DEC 1991 |
| Times Cited: 57 References: 32 |
| Abstract: Genetic studies on Drosophila Abl and, more recently, on mouse c-Abl and c-Src indicate that the functions of these non-receptor tyrosine kinases may duplicate activities of other molecules within signal transduction pathways. In Drosophila, second-site mutations have been recovered that disrupt the redundant functions so that the Abl tyrosine kinase is essential to the formation of axonal connections in the embryonic central nervous system and for attachment of embryonic muscles to the body wall. Molecular isolation and analysis of the genes identified by these second-site mutations should define the molecular basis for the genetic redundancy. |
| Document Type: Review |
| Language: English |
| Reprint Address: HOFFMANN, FM (reprint author), UNIV WISCONSIN, MCARDLE LAB CANC RES, MADISON, WI 53706 USA |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Genetics & Heredity |
| IDS Number: GN927 |
| ISSN: 0168-9525 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |