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| INVIVO LOSS OF TELOMERIC REPEATS WITH AGE IN HUMANS |
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| Author(s): LINDSEY J, MCGILL NI, LINDSEY LA, GREEN DK, COOKE HJ |
| Source: MUTATION RESEARCH Volume: 256 Issue: 1 Pages: 45-48 Published: JAN 1991 |
| Times Cited: 285 References: 12 |
| Abstract: Telomeric DNA in the skin cells of 21 human subjects aged between 0 and 92 years was quantified by determining the length of the telomeric smear and the relative amount of TTAGGG repeat sequences. Both telomere length and quantity of telomeric repeat sequences were found to decrease significantly with age. Telomere loss has previously been postulated to be a cause of cell senescence. |
| Document Type: Article |
| Language: English |
Addresses:
1. WESTERN GEN HOSP, MRC, HUMAN GENET UNIT, CREWE RD, EDINBURGH EH4 2XU, MIDLOTHIAN SCOTLAND
2. BANGOUR GEN HOSP, PLAST SURG UNIT, BROXBURN, SCOTLAND |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Genetics & Heredity; Toxicology |
| IDS Number: GP654 |
| ISSN: 0921-8262 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |