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| AUTOANTIBODIES TO NATIVE MYELOPEROXIDASE IN PATIENTS WITH PULMONARY HEMORRHAGE AND ACUTE-RENAL-FAILURE |
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| Author(s): ROBERTS DE, PEEBLES C, CURD JG, TAN EM, RUBIN RL |
| Source: JOURNAL OF CLINICAL IMMUNOLOGY Volume: 11 Issue: 6 Pages: 389-397 Published: NOV 1991 |
| Times Cited: 18 References: 35 |
| Abstract: Sera from 245 patients were screened by indirect immunofluorescence for perinuclear/nuclear staining (P-ANCA) of ethanol-fixed neutrophils, a staining pattern which is associated with the presence of antibodies to myeloperoxidase. Using immunoblot and immunoprecipitation techniques on 15 P-ANCA-positive sera, 13 patients demonstrated antibody to purified or native myeloperoxidase but not to denatured myeloperoxidase. In patients with P-ANCA, the most frequent reason for medical attention was hemoptysis (8/13; 62%). Of the 15 sera with P-ANCA, acute renal failure was identified in 9 patients (60%). Five patients (33%) had both. All patients (eight of eight) with hemoptysis had antibodies which bound functional MPO as compared to three of seven P-ANCA-positive patients without hemoptysis (P < 0.001), suggesting that antibodies which recognize conformational sites on native myeloperoxidase occur in a subgroup of patients with alveolar hemorrhage as their presenting clinical sign. These findings may provide insight into the disease process associated with P-ANCA. We further identify a subgroup of patients with a severe pulmonorenal syndrome and antibodies recognizing native myeloperoxidase. |
| Document Type: Article |
| Language: English |
Addresses:
1. SCRIPPS RES INST, WM KECK AUTOIMMUNE DIS CTR, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA |
| Publisher: PLENUM PUBL CORP, 233 SPRING ST, NEW YORK, NY 10013 |
| Subject Category: Immunology |
| IDS Number: GP693 |
| ISSN: 0271-9142 |
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