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| FTSZ RING STRUCTURE ASSOCIATED WITH DIVISION IN ESCHERICHIA-COLI |
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| Author(s): BI E, LUTKENHAUS J |
| Source: NATURE Volume: 354 Issue: 6349 Pages: 161-164 Published: NOV 14 1991 |
| Times Cited: 563 References: 23 |
| Abstract: GENES for cell division have been identified in Escherichia coli by the isolation of conditional lethal mutations that block cell division, but do not affect DNA replication or segregation 1. Of these genes, ftsZ is of great interest as it acts earliest in the division pathway 2,3, is essential 4, its level dictates the frequency of division 5,6, and it is thought to be the target of two cell-division inhibitors 7-9, SulA, produced in response to DNA damage 10, and MinCD, which prevents division at old sites 11. Here we have used immunoelectronmicroscopy to localize the FtsZ protein to the division site. The results suggest that FtsZ self-assembles into a ring structure at the future division site and may function as a cytoskeletal element. The formation of this ring may be the point at which division is regulated. |
| Document Type: Article |
| Language: English |
| Reprint Address: BI, E (reprint author), UNIV KANSAS, MED CTR, DEPT MICROBIOL MOLEC GENET & IMMUNOL, KANSAS CITY, KS 66103 USA |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: GP880 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |