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| RAS1 AND A PUTATIVE GUANINE-NUCLEOTIDE EXCHANGE FACTOR PERFORM CRUCIAL STEPS IN SIGNALING BY THE SEVENLESS PROTEIN TYROSINE KINASE |
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| Author(s): SIMON MA, BOWTELL DDL, DODSON GS, LAVERTY TR, RUBIN GM |
| Source: CELL Volume: 67 Issue: 4 Pages: 701-716 Published: NOV 15 1991 |
| Times Cited: 624 References: 57 |
| Abstract: We have conducted a genetic screen for mutations that decrease the effectiveness of signaling by a protein tyrosine kinase, the product of the Drosophila melanogaster sevenless gene. These mutations define seven genes whose wild-type products may be required for signaling by sevenless. Four of the seven genes also appear to be essential for signaling by a second protein tyrosine kinase, the product of the Ellipse gene. The putative products of two of these seven genes have been identified. One encodes a ras protein. The other locus encodes a protein that is homologous to the S. cerevisiae CDC25 protein, an activator of guanine nucleotide exchange by ras proteins. These results suggest that the stimulation of ras protein activity is a key element in the signaling by sevenless and Ellipse and that this stimulation may be achieved by activating the exchange of GTP for bound GDP by the ras protein. |
| Document Type: Article |
| Language: English |
| Reprint Address: SIMON, MA (reprint author), UNIV CALIF BERKELEY, HOWARD HUGHES MED INST, BERKELEY, CA 94720 USA |
Addresses:
1. UNIV CALIF BERKELEY, DEPT MOLEC & CELL BIOL, BERKELEY, CA 94720 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: GQ407 |
| ISSN: 0092-8674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |