| GOSSYPOL AND DERIVATIVES - A NEW CLASS OF ALDOSE REDUCTASE INHIBITORS |
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| Author(s): DECK LM, VANDERJAGT DL, ROYER RE |
| Source: JOURNAL OF MEDICINAL CHEMISTRY Volume: 34 Issue: 11 Pages: 3301-3305 Published: NOV 1991 |
| Times Cited: 26 References: 26 |
| Abstract: Gossypol and 17 derivatives were tested as inhibitors of aldose reductase from human placenta. Gossypol and a number of the derivatives were potent inhibitors. The order of inhibitory activity was interpreted in relation to the Kador-Sharpless pharmacophor model for the aldose reductase inhibitor site. The structural but not the electronic aspects of the model were found to apply to this series of compounds. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV NEW MEXICO, SCH MED, DEPT BIOCHEM, ALBUQUERQUE, NM 87131 USA |
| Publisher: AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 |
| Subject Category: Chemistry, Medicinal |
| IDS Number: GQ615 |
| ISSN: 0022-2623 |