| THE EXTRAORDINARY ENZYMES INVOLVED IN ERYTHROMYCIN BIOSYNTHESIS |
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| Author(s): STAUNTON J |
| Source: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH Volume: 30 Issue: 10 Pages: 1302-1306 Published: OCT 1991 |
| Times Cited: 43 References: 14 |
| Abstract: Nature's secret of how highly complicated molecules like erythromycin A are synthesized is no longer completely safe. Lately good progress has been made towards understanding the synthesis of polyketides (to which erythromycin A belongs) by polyketide synthases (PKS). Fatty acids are synthesized along similar lines. However, erythromycin-PKS is a covalently bonded giant protein (cassette/module organization) that shows many enzyme activities. The molecule's skeleton is built up in several reaction cycles by this giant protein. |
| Document Type: Article |
| Language: English |
| Reprint Address: STAUNTON, J (reprint author), UNIV CAMBRIDGE, CHEM LAB, LENSFIELD RD, CAMBRIDGE CB2 1EW, ENGLAND |
| Publisher: VCH PUBLISHERS INC, 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 |
| Subject Category: Chemistry, Multidisciplinary |
| IDS Number: GQ707 |
| ISSN: 0570-0833 |