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| E-CADHERIN EXPRESSION IN SQUAMOUS-CELL CARCINOMAS OF HEAD AND NECK - INVERSE CORRELATION WITH TUMOR DEDIFFERENTIATION AND LYMPH-NODE METASTASIS |
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| Author(s): SCHIPPER JH, FRIXEN UH, BEHRENS J, UNGER A, JAHNKE K, BIRCHMEIER W |
| Source: CANCER RESEARCH Volume: 51 Issue: 23 Pages: 6328-6337 Published: DEC 1 1991 |
| Times Cited: 456 References: 39 |
| Abstract: Tissue sections of 32 squamous cell carcinomas (SCCs) of the head and neck were investigated for the expression of the epithelium-specific cell adhesion molecule E-cadherin. We found that E-cadherin expression is inversely correlated both with the loss of differentiation of the tumor and with lymph node metastasis. The well-differentiated SCCs expressed E-cadherin, often as strongly as the normal stratified epithelium (12 cases were tested); the moderately differentiated SCCs expressed intermediate amounts of E-cadherin or were heterogeneous (15 cases were analyzed); whereas the poorly differentiated SCCs were all E-cadherin-negative ( five cases were investigated). Furthermore, seven of eight infiltrated lymph nodes of SCCs were E-cadherin-negative. These data indicate that the loss of the cell adhesion molecule E-cadherin in fact plays an important role in the progression of human squamous cell carcinomas, ie., that down-regulation of expression is associated with dedifferentiation and metastasis of the tumor cells in vivo. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV ESSEN GESAMTHSCH, SCH MED, INST ZELLBIOL, VIRCHOWSTR 173, W-4300 ESSEN 1, GERMANY
2. UNIV ESSEN GESAMTHSCH, SCH MED, DEPT OTORHINOLARYNGOL, W-4300 ESSEN 1, GERMANY |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: GR475 |
| ISSN: 0008-5472 |
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