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| LYMPHOID GERMINAL-CENTERS ARE RESERVOIRS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 RNA |
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| Author(s): FOX CH, TENNERRACZ K, RACZ P, FIRPO A, PIZZO PA, FAUCI AS |
| Source: JOURNAL OF INFECTIOUS DISEASES Volume: 164 Issue: 6 Pages: 1051-1057 Published: DEC 1991 |
| Times Cited: 260 References: 26 |
| Abstract: When radiolabeled RNA was used for in situ hybridization, human immunodeficiency virus type 1 (HIV-1) RNA was found in high concentrations in germinal centers of lymphoid tissues from patients with HIV-1 infection. Most of the signal from hybridized probe was independent of specific cells, being found in the extracellular space of germinal centers in all lymphoid tissues examined from adult patients with Centers for Disease Control (CDC) class 11 and ill disease or pediatric patients with CDC class P-2A disease. Lymphoid tissues from adult patients with CDC class IV infections or pediatric patients with CDC class P-2D disease (including autopsy material) lacked intact germinal centers, and HIV-1 RNA was then found only in rare, isolated cells, with some tissues having no detectable HIV-1 RNA. Thus, in the early stages of HIV infection, germinal centers serve as important reservoirs of free virus in the interstitial spaces, and this reservoir disappears as the germinal centers involute with advancing disease. |
| Document Type: Article |
| Language: English |
Addresses:
1. NIAID, IMMUNOREGULAT LAB, BETHESDA, MD 20892 USA
2. NCI, PEDIAT BRANCH, BETHESDA, MD 20892 USA
3. ALLGEMEINES KRANKENHAUS ST GEORG, DEPT HEMATOL, HAMBURG, GERMANY
4. BERNHARD NOCHT INST TROP MED, DEPT PATHOL, HAMBURG, GERMANY
5. WALTER REED ARMY MED CTR, ARMED FORCES INST PATHOL, DIV AIDS, WASHINGTON, DC USA
6. BERNARD NOCHT INST TROP MED, KORBER LAB, HAMBURG, GERMANY |
| Publisher: UNIV CHICAGO PRESS, 5720 S WOODLAWN AVE, CHICAGO, IL 60637 |
| Subject Category: Infectious Diseases |
| IDS Number: GR660 |
| ISSN: 0022-1899 |
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