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| APPLICABILITY OF THE COEFFICIENT OF VARIATION METHOD FOR ANALYZING SYNAPTIC PLASTICITY |
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| Author(s): FABER DS, KORN H |
| Source: BIOPHYSICAL JOURNAL Volume: 60 Issue: 5 Pages: 1288-1294 Published: NOV 1991 |
| Times Cited: 154 References: 18 |
| Abstract: The classical coefficient of variation method for "quantal" analysis of synaptic responses allows unambiguous identification of pre- and post synaptic loci underlying synaptic plasticity only when extensives implifying restrictions are made. They include invariance of quantal parameters and the assumption that a single afferent produces the evoked potentials or currents. More general theoretical formulations and simulations demonstrate that the standard criteria do not always provide useful guidelines because when the other sources of physiological variance are included, putative pre- and postsynaptic domains may overlap, For example, data typically interpreted as indicating modifications at both sites can be due to a mechanism localized to only one of the two, if parameter variances are taken into consideration in the case of a single input cell, or if there are multiple inputs and the stimulus does not activate all of them reliably, With this perspective, other physiologically realistic hypotheses relevant to the expression of synaptic plasticity, such as that during long-term potentiation, can be envisioned. |
| Document Type: Note |
| Language: English |
| Reprint Address: FABER, DS (reprint author), SUNY BUFFALO, DEPT PHYSIOL, NEUROBIOL LAB, BUFFALO, NY 14214 USA |
Addresses:
1. INST PASTEUR, DEPT BIOTECHNOL, NEUROBIOL CELLULAIRE LAB, INSERM, F-75724 PARIS 15, FRANCE |
| Publisher: BIOPHYSICAL SOCIETY, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 |
| Subject Category: Biophysics |
| IDS Number: GR685 |
| ISSN: 0006-3495 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |