| | |  | | | | Record from Web of Science® | | | | | | |
| CHARACTERIZATION OF A ZINC FINGER GENE DISRUPTED BY THE T(15,17) IN ACUTE PROMYELOCYTIC LEUKEMIA |
|
|
| Author(s): GODDARD AD, BORROW J, FREEMONT PS, SOLOMON E |
| Source: SCIENCE Volume: 254 Issue: 5036 Pages: 1371-1374 Published: NOV 29 1991 |
| Times Cited: 370 References: 49 |
| Abstract: The translocation t(15;17) associated with acute promyelocytic leukemia results in the fusion of the retinoic acid receptor alpha (RARA) gene to the PML gene. Characterization of PML revealed that it is a putative zinc finger protein and potential transcription factor that is commonly expressed, with at least three major transcription products. PML breakpoints cluster in two regions on either side of an alternatively spliced exon. Although leukemic cells with translocations characteristically express only one fusion product, both PML/RARA (on the 15q+ derivative chromosome) and RARA/PML (on the 17q- derivative) are transcribed. |
| Document Type: Article |
| Language: English |
Addresses:
1. IMPERIAL CANC RES FUND, SOMAT CELL GENET LAB, LONDON WC2A 3PX, ENGLAND
2. IMPERIAL CANC RES FUND, PROT STRUCT LAB, LONDON WC2A 3PX, ENGLAND |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: GR777 |
| ISSN: 0036-8075 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |