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| EARLY RENAL MEDULLARY HYPOXIC INJURY FROM RADIOCONTRAST AND INDOMETHACIN |
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| Author(s): HEYMAN SN, BREZIS M, EPSTEIN FH, SPOKES K, SILVA P, ROSEN S |
| Source: KIDNEY INTERNATIONAL Volume: 40 Issue: 4 Pages: 632-642 Published: OCT 1991 |
| Times Cited: 152 References: 43 |
| Abstract: We evaluated the acute changes in cortical and outer medullary oxygen tension and the alterations in renal function and morphology within the first 90 minutes after the administration of indomethacin and iothalamate to anesthetized Sprague-Dawley rats. Both agents were found to produce marked and protracted outer medullary hypoxia averaging 12 +/- 4 and 9 +/- 2 mm Hg, respectively (mean +/- SE). Given together to salt depleted uninephrectomized rats they produced an early hypoxic injury localized selectively in the outer medulla. This lesion progressed from 3 +/- 1% of medullary thick ascending limbs (mTALs) at 15 minutes to 22 +/- 7% at 24 hours. Condensed "dark" cells were observed at 15 minutes, probably representing a type of early injury. Residual red cell mass, quantified in the outer medullary vasculature of perfusion-fixed kidneys and presumably reflecting stasis, was substantially increased in iothalamate treated rats. Red cells mass in the interbundle zone correlated with mTAL necrosis. Taken together, these results show an early period of medullary hypoxia, accompanied by a selective injury to mTALs in the central interbundle zone with apparent stasis. These findings contrast sharply with the ischemia-reflow pattern of renal damage and emphasize the important role of medullary hypoxia in the genesis of acute renal failure in this model. |
| Document Type: Article |
| Language: English |
Addresses:
1. BETH ISRAEL HOSP, DEPT PATHOL, 330 BROOKLINE AVE, BOSTON, MA 02215 USA
2. HARVARD UNIV, SCH MED, DANA FARBER CANC INST, DEPT MED, BOSTON, MA 02115 USA
3. HARVARD UNIV, SCH MED, DANA FARBER CANC INST, DEPT PATHOL, BOSTON, MA 02115 USA
4. HEBREW UNIV JERUSALEM, HADASSAH UNIV HOSP, SCH MED, HARVARD CTR STUDY KIDNEY DIS, JERUSALEM, ISRAEL
5. HEBREW UNIV JERUSALEM, HADASSAH UNIV HOSP, SCH MED, DEPT MED, JERUSALEM, ISRAEL |
| Publisher: BLACKWELL SCIENCE INC, 238 MAIN ST, CAMBRIDGE, MA 02142 |
| Subject Category: Urology & Nephrology |
| IDS Number: GT736 |
| ISSN: 0085-2538 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |