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| NEUROTROPHIN-5 - A NOVEL NEUROTROPHIC FACTOR THAT ACTIVATES TRK AND TRKB |
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| Author(s): BERKEMEIER LR, WINSLOW JW, KAPLAN DR, NIKOLICS K, GOEDDEL DV, ROSENTHAL A |
| Source: NEURON Volume: 7 Issue: 5 Pages: 857-866 Published: NOV 1991 |
| Times Cited: 686 References: 59 |
| Abstract: In vertebrates, the formation and maintenance of neuronal connections are subject to regulation by multiple target-derived, diffusible (neurotrophic) factors. Here we describe the identification and characterization of a novel neurotrophic factor designated neurotrophin-5 (NT-5). NT-5 is structurally related to nerve growth factor and is expressed in embryonic as well as adult tissues. Recombinant NT-5 promotes the survival of peripheral sensory and sympathetic neurons and induces differentiation of the pheochromocytoma cell line PC12. NT-5 activates two trk-related tyrosine kinase receptors and shares these receptors with other neurotrophins. Activation of multiple receptors may permit a single neurotrophin to control target innervation by distinct neuronal populations. Receptor sharing could enable neurotrophic factors emanating from distinct targets to cooperate in regulating neurons with multiple connections. |
| Document Type: Article |
| Language: English |
| Reprint Address: BERKEMEIER, LR (reprint author), GENENTECH INC, DEPT MOLEC BIOL, S SAN FRANCISCO, CA 94080 USA |
Addresses:
1. GENENTECH INC, DEPT DEV BIOL, S SAN FRANCISCO, CA 94080 USA
2. NCI, FREDERICK CANC RES & DEV CTR, ABL BASIC RES PROGRAM, MMCL, FREDERICK, MD 21701 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Neurosciences |
| IDS Number: GT939 |
| ISSN: 0896-6273 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |