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| IDENTIFICATION OF THE MOTILITY-RELATED PROTEIN (MRP-1), RECOGNIZED BY MONOCLONAL-ANTIBODY M31-15, WHICH INHIBITS CELL MOTILITY |
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| Author(s): MIYAKE M, KOYAMA M, SENO M, IKEYAMA S |
| Source: JOURNAL OF EXPERIMENTAL MEDICINE Volume: 174 Issue: 6 Pages: 1347-1354 Published: DEC 1 1991 |
| Times Cited: 161 References: 39 |
| Abstract: A murine monoclonal antibody (M31-15) was identified using the penetration-inhibiting assay of a human lung adenocarcinoma cell line (MAC10) and remarkably inhibited the phagokinetic tract motility of various cancer cell lines. The antigen, motility-related protein (MRP-1), recognized by M31-15, was 25- and 28-kD proteins, and M31-15 was used to isolate a cDNA clone from a human breast carcinoma cDNA library. Sequence analysis revealed that MRP-1 had strong similarity with a B cell surface antigen (CD37), a melanoma-associated antigen (ME491), the target of an antiproliferative antibody (TAPA-1), a human tumor-associated antigen (CO-029), and the Sm23 antigen of the trematode parasite Schistosoma mansoni. |
| Document Type: Article |
| Language: English |
| Reprint Address: MIYAKE, M (reprint author), KITANO HOSP, TAZUKE KOFUKAI MED RES INST, DEPT THORAC SURG, 13-3 KAMIYAMACHO, KITA KU, OSAKA 530, JAPAN |
Addresses:
1. TAKEDA CHEM IND LTD, DIV RES & DEV, BIOTECHNOL RES LABS, OSAKA 530, JAPAN |
| Publisher: ROCKEFELLER UNIV PRESS, 222 E 70TH STREET, NEW YORK, NY 10021 |
| Subject Category: Immunology; Medicine, Research & Experimental |
| IDS Number: GU644 |
| ISSN: 0022-1007 |
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