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| HUMAN-IMMUNODEFICIENCY-VIRUS GENETIC-VARIATION THAT CAN ESCAPE CYTOTOXIC T-CELL RECOGNITION |
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| Author(s): PHILLIPS RE, ROWLANDJONES S, NIXON DF, GOTCH FM, EDWARDS JP, OGUNLESI AO, ELVIN JG, ROTHBARD JA, BANGHAM CRM, RIZZA CR, MCMICHAEL AJ |
| Source: NATURE Volume: 354 Issue: 6353 Pages: 453-459 Published: DEC 12 1991 |
| Times Cited: 745 References: 43 |
| Abstract: In a longitudinal study of HIV seropositive patients, there were fluctuations in the specificity of cytotoxic T cells for the virus. This was matched by variability in proviral gag DNA epitope sequences in the lymphocytes of these patients. Some of these viral variants are not recognized by autologous T cells. Accumulation of such mutations in T-cell antigenic targets would provide a mechanism for immune escape. |
| Document Type: Article |
| Language: English |
| Reprint Address: PHILLIPS, RE (reprint author), UNIV OXFORD, JOHN RADCLIFFE HOSP, INST MOLEC MED, MOLEC IMMUNOL GRP, OXFORD OX3 9DU, ENGLAND |
Addresses:
1. IMMULOGIC, PALO ALTO, CA 94304 USA
2. CHURCHILL HOSP, OXFORD HAEMOPHILIA CTR, OXFORD OX3 7LV, ENGLAND |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: GV078 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |