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| HOMOLOGY OF A CANDIDATE SPERMATOGENIC GENE FROM THE MOUSE Y-CHROMOSOME TO THE UBIQUITIN-ACTIVATING ENZYME-E1 |
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| Author(s): MITCHELL MJ, WOODS DR, TUCKER PK, OPP JS, BISHOP CE |
| Source: NATURE Volume: 354 Issue: 6353 Pages: 483-486 Published: DEC 12 1991 |
| Times Cited: 133 References: 33 |
| Abstract: THE Sxr (sex-reversed) region, a fragment of the Y chromosome short arm, can cause chromosomally female XXSxr or XSxrO mice to develop as sterile males 1-3. The original Sxr region, termed Sxr(a), encodes: Tdy, the primary sex-determining gene; Hya, the controlling or structural locus for the minor transplantation antigen H-Y (ref. 4); gene(s) controlling the expression of the serologically detected male antigen (SDMA) 5; Spy, a gene(s) required for the survival and proliferation of A spermatogonia during spermatogenesis 6,7; Zfy-1/Zfy-2, zinc-finger-containing genes of unknown function 8; and Sry, which is probably identical to Tdy (ref. 9). A deletion variant 10 of Sxr(a), termed Sxr(b), which lacks Hya, SDMA expression, Spy and some Zfy-2 sequences, makes positional cloning of these genes possible. We report here the isolation of a new testis-specific gene, Sby, mapping to the DNA deleted from the Sxr(b) region (the DELTA-Sxr(b) interval). Sby has extensive homology to the X-linked human ubiquitin-activating enzyme E1 (ref. 11). The critical role of this enzyme in nuclear DNA replication 12 together with the testis-specific expression of Sby suggests Sby as a candidate for the spermatogenic gene Spy. |
| Document Type: Article |
| Language: English |
| Reprint Address: MITCHELL, MJ (reprint author), UNIV TENNESSEE, DEPT OBSTET GYNECOL, DIV REPROD GENET, MOLEC GENET RES LAB, MEMPHIS, TN 38105 USA |
Addresses:
1. INST PASTEUR, INSERM, U276, UNITE IMMUNOGENET HUMAINE, PARIS 15, FRANCE
2. UNIV MICHIGAN, MUSEUM ZOOL, ANN ARBOR, MI 48109 USA
3. UNIV MICHIGAN, DEPT BIOL, ANN ARBOR, MI 48109 USA |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: GV078 |
| ISSN: 0028-0836 |
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