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| A CANDIDATE SPERMATOGENESIS GENE ON THE MOUSE Y-CHROMOSOME IS HOMOLOGOUS TO UBIQUITIN-ACTIVATING ENZYME-E1 |
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| Author(s): KAY GF, ASHWORTH A, PENNY GD, DUNLOP M, SWIFT S, BROCKDORFF N, RASTAN S |
| Source: NATURE Volume: 354 Issue: 6353 Pages: 486-489 Published: DEC 12 1991 |
| Times Cited: 104 References: 30 |
| Abstract: THE human X-linked gene A1S9 (refs 1-3) complements a temperature-sensitive cell-cycle mutation in mouse L cells 4, and encodes the ubiquitin-activating enzyme E1 (refs 5-7). The gene has been reported to escape X-chromosome inactivation 8, but there is some conflicting evidence 9. We have isolated part of the mouse A1s9 gene, mapped it to the proximal portion of the X chromosome and shown that it undergoes normal X-inactivation. We also detected two copies of the gene on the short arm of the mouse Y chromosome (A1s9Y-1 and A1s9Y-2). The functional A1s9Y gene (Als9Y-1) is expressed in testis and is lost in the deletion mutant Sxr(b) (ref. 10). Therefore A1s9Y-1 is a candidate for the spermatogenesis gene, Spy, which maps to this region. A1s9X is similar to the Zfx gene in undergoing X-inactivation 11,12, yet having homologous sequences on the short arm of the Y chromosome 13,14, which are expressed in the testis. These Y-linked genes may form part of a coregulated group of genes which function during spermatogenesis. |
| Document Type: Article |
| Language: English |
| Reprint Address: RASTAN, S (reprint author), MRC, CLIN RES CTR, COMPARAT BIOL SECT, HARROW HA1 3UJ, MIDDX ENGLAND |
Addresses:
1. MRC, CLIN RES CTR, COMPARAT BIOL SECT, HARROW HA1 3UJ, MIDDX ENGLAND
2. INST CANC RES, CHESTER BEATTY LABS, LONDON SW3 6JB, ENGLAND |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: GV078 |
| ISSN: 0028-0836 |
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