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| 2 ALTERNATIVELY SPLICED MOUSE UROKINASE RECEPTOR MESSENGER-RNAS WITH DIFFERENT HISTOLOGICAL LOCALIZATION IN THE GASTROINTESTINAL-TRACT |
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| Author(s): KRISTENSEN P, ERIKSEN J, BLASI F, DANO K |
| Source: JOURNAL OF CELL BIOLOGY Volume: 115 Issue: 6 Pages: 1763-1771 Published: DEC 1991 |
| Times Cited: 109 References: 61 |
| Abstract: Two mouse urokinase-type plasminogen activator receptor (muPAR) cDNAs were isolated: muPAR1 is homologous to the human urokinase-type plasminogen activator receptor while muPAR2 codes for a 199 residue protein sharing the first 133 residues with muPAR1. Mouse genomic DNA sequencing indicates that the two different mRNAs arise by alternative splicing. In situ hybridization showed differential expression of die two mRNAs in mouse gastric mucosa. muPAR1 mRNA is located in luminal epithelial cells situated close to urokinase-type plasminogen activator-producing connective tissue cells of the lamina propria, pointing to plasmin generation controlled by the cooperation of different cells that may play a role in the release of gastric epithelial cells. muPAR2 mRNA is expressed in the basal epithelial cells, and the deduced protein sequence includes the receptor ligand binding domain, but omits the region involved in glycolipid-mediated membrane anchoring, suggesting that muPAR2 may code for a secreted uPA binding protein. |
| Document Type: Article |
| Language: English |
| Reprint Address: KRISTENSEN, P (reprint author), CNS DIV, DEPT PATHOL & HISTOCHEM, NOVO NORDISK, DENMARK |
Addresses:
1. RIGSHOSP, FINSEN LAB, DK-2100 COPENHAGEN, DENMARK
2. UNIV COPENHAGEN, INST MICROBIOL, DK-1168 COPENHAGEN, DENMARK |
| Publisher: ROCKEFELLER UNIV PRESS, 222 E 70TH STREET, NEW YORK, NY 10021 |
| Subject Category: Cell Biology |
| IDS Number: GW007 |
| ISSN: 0021-9525 |
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