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| EFFECTS ON DONORS OF 2ND BONE-MARROW COLLECTIONS |
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| Author(s): STRONCEK DF, MCGLAVE P, RAMSAY N, MCCULLOUGH J |
| Source: TRANSFUSION Volume: 31 Issue: 9 Pages: 819-822 Published: NOV-DEC 1991 |
| Times Cited: 6 References: 16 |
| Abstract: Second bone marrow transplants have been used successfully to treat marrow graft failure or relapse following the original marrow transplantation. Hospital records of 16 related two-time bone marrow donors were reviewed to determine what risks a person faces in making a second marrow donation. One donor suffered a minor complication following the first collection, but no donors suffered complications during the second donation. The volume of marrow collected for the first and second donations ( 1253 +/- 504 vs. 1261 +/- 471 mL) was similar. However, more marrow donors received transfusions of homologous red cells during the second collection than during the first collection (5/16 compared to 1/16; p = 0.06). To determine what factors might contribute to the high incidence of homologous red cell transfusion dunn second donations, the experiences of donors who received homologous blood dunn the second donation were compared to the experiences of donors who received only autologous blood. Persons receiving homologous blood during the second collection received more red cell units than persons receiving autologous blood (2.0 +/- 0.7 units compared to 0.9 +/- 0.5 units; p < 0.01). Their precollection hemoglobin levels were lower (12.3 +/- 1.2 vs. 14.4 +/- 1.4 g/dL [123 +/- 12 vs. 144 +/- 14 g/L]; p < 0.01), and the time between the first and second collections was significantly less (45 +/- 8 days vs. 342 +/- 432 days; p < 0.05). Further analysis showed that five of eight persons who donated marrow a second time within 60 days of the first donation were transfused with homologous blood, while none of eight persons who donated bone marrow more than 60 days after their first donation were transfused with homologous blood (p < 0.5). These results suggest that people can safely donate marrow a second time; however, if the second marrow collection occurs within 60 days of the first collection, precautions should be taken to reduce the chances of exposing the marrow donor to homologous blood. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV MINNESOTA, SCH MED, DEPT LAB MED & PATHOL, MINNEAPOLIS, MN 55455 USA
2. UNIV MINNESOTA, SCH MED, DEPT MED, MINNEAPOLIS, MN 55455 USA
3. UNIV MINNESOTA, SCH MED, DEPT PEDIAT, MINNEAPOLIS, MN 55455 USA
4. AMER RED CROSS, ST PAUL REG BLOOD SERV, ST PAUL, MN USA |
| Publisher: AMER ASSOC BLOOD BANKS, 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 |
| Subject Category: Hematology |
| IDS Number: GW178 |
| ISSN: 0041-1132 |
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