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| A NOVEL PUTATIVE TYROSINE KINASE RECEPTOR WITH ONCOGENIC POTENTIAL |
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| Author(s): JANSSEN JWG, SCHULZ AS, STEENVOORDEN ACM, SCHMIDBERGER M, STREHL S, AMBROS PF, BARTRAM CR |
| Source: ONCOGENE Volume: 6 Issue: 11 Pages: 2113-2120 Published: NOV 1991 |
| Times Cited: 138 References: 42 |
| Abstract: We have detected transforming activity by a tumorigenicity assay using NIH3T3 cells transfected with DNA from a chronic myeloproliferative disorder patient. Here, we report the cDNA cloning of the corresponding oncogene, designated UFO, in allusion to the as yet unidentified function of its protein. Nucleotide sequence analysis of a 3116 bp cDNA clone revealed a 2682-bp-long open reading frame capable of directing the synthesis of a 894 amino acid polypeptide. The predicted UFO protein exhibits characteristic features of a transmembrane receptor with associated tyrosine kinase activity. The UFO proto-oncogene maps to human chromosome 19q13.1 and is transcribed into two 5.0 kb and 3.2 kb mRNAs in human bone marrow and human tumor cell lines. The UFO locus is evolutionarily conserved between vertebrate species. A 4.0 kb mRNA of the murine UFO homolog is expressed in a variety of different mouse tissues. We thus have identified a novel element of the complex signaling network involved in the control of cell proliferation and differentiation. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV ULM, DEPT PEDIAT 2, INTERNAL DIS PROPEDEUT SECT, PRITTWITZSTR 43, W-7900 ULM, GERMANY
2. DEPT TRANSFUS MED, W-7900 ULM, GERMANY
3. CHILDRENS CANC RES INST, A-1090 VIENNA, AUSTRIA |
| Publisher: STOCKTON PRESS, HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS |
| Subject Category: Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity |
| IDS Number: GX119 |
| ISSN: 0950-9232 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |