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| RXR-BETA - A COREGULATOR THAT ENHANCES BINDING OF RETINOIC ACID, THYROID-HORMONE, AND VITAMIN-D RECEPTORS TO THEIR COGNATE RESPONSE ELEMENTS |
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| Author(s): YU VC, DELSERT C, ANDERSEN B, HOLLOWAY JM, DEVARY OV, NAAR AM, KIM SY, BOUTIN JM, GLASS CK, ROSENFELD MG |
| Source: CELL Volume: 67 Issue: 6 Pages: 1251-1266 Published: DEC 20 1991 |
| Times Cited: 1,135 References: 78 |
| Abstract: The retinoic acid receptor (RAR) requires coregulators to bind effectively to response elements in target genes. A strategy of sequential screening of expression libraries with a retinoic acid response element and RAR identified a cDNA encoding a coregulator highly related to RXR-alpha. This protein, termed RXR-beta, forms heterodimers with RAR, preferentially increasing its DNA binding and transcriptional activity on promoters containing retinoic acid, but not thyroid hormone or vitamin D, response elements. Remarkably, RXR-beta also heterodimerizes with the thyroid hormone and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. RXR-alpha also forms heterodimers with these receptors. These observations suggest that retinoid X receptors meet the criteria for biochemically characterized cellular coregulators and serve to selectively target the high affinity binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate DNA response elements. |
| Document Type: Article |
| Language: English |
| Reprint Address: YU, VC (reprint author), UNIV CALIF SAN DIEGO, HOWARD HUGHES MED INST, LA JOLLA, CA 92093 USA |
Addresses:
1. UNIV CALIF SAN DIEGO, EUKARYOT REGULATORY BIOL PROGRAM, LA JOLLA, CA 92093 USA
2. UNIV CALIF SAN DIEGO, DEPT MED, LA JOLLA, CA 92093 USA
3. UNIV CALIF SAN DIEGO, DEPT CHEM, LA JOLLA, CA 92093 USA
4. UNIV CALIF SAN DIEGO, MOLEC PATHOL GRP, LA JOLLA, CA 92093 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: GX164 |
| ISSN: 0092-8674 |
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