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| ADENOSINE TRIPHOSPHATE-SENSITIVE POTASSIUM CHANNELS IN THE CARDIOVASCULAR-SYSTEM |
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| Author(s): NICHOLS CG, LEDERER WJ |
| Source: AMERICAN JOURNAL OF PHYSIOLOGY Volume: 261 Issue: 6 Pages: H1675-H1686 Part: Part 2 Published: DEC 1991 |
| Times Cited: 455 References: 157 |
| Abstract: ATP is normally available in cells at millimolar concentrations and is "buffered" by intracellular pools of other high-energy phosphates, such as creatine phosphate. Thus intracellular [ATP] ([ATP]i) may seem an unlikely candidate for a regulatory signal inside cells. Recent evidence suggests, however, that [ATP]i regulates the behavior of a class of potassium (K(ATP)) channels that are found throughout the cardiovascular system. K(ATP) channels are present in cardiac, skeletal, and vascular smooth muscle. The channels are inhibited by micromolar [ATP]i, and this inhibition is relieved by micromolar [ADP]i. We present evidence in support of the idea that variations of [ATP]i and [ADP]i, even within normal concentration ranges, may influence cellular function in the heart and vascular system via a direct action on the K(ATP) channel. Furthermore, very specific modulators of K(ATP) channel activity are available. We discuss the mechanism of action of these agents and their interaction with endogenous modulators and consider their potential roles in cardiovascular therapy. |
| Document Type: Review |
| Language: English |
| Reprint Address: NICHOLS, CG (reprint author), WASHINGTON UNIV, SCH MED, DEPT CELL BIOL & PHYSIOL, BOX 8228, 660 S EUCLID AVE, ST LOUIS, MO 63110 USA |
Addresses:
1. UNIV MARYLAND, DEPT PHYSIOL, BALTIMORE, MD 21201 USA |
| Publisher: AMER PHYSIOLOGICAL SOC, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 |
| Subject Category: Physiology |
| IDS Number: GX687 |
| ISSN: 0002-9513 |
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